KEY PUBLICATIONS
PUBLICATIONS
Names of lab members are bolded
2022
Functional consequences of postnatal interventions in a mouse model of Fragile X syndrome. Rais M, Lovelace JW, Shuai SX, Woodard W, Bishay S, Estrada L, Sharma AR, Nguyen AQ, Kulinich AO, Pirbhoy PS, Palacios AR, Nelson DL, Razak KA, Ethell IM. Neurobiol dis 162, 105577.
2021
Cortical interneurons in autism. Contractor A, Ethell IM, Portera-Cailliau C. Nat neurosci 24 (12), 1648-1659
Neural Correlates of Auditory Hypersensitivity in Fragile X Syndrome. Razak KA, Binder DK, Ethell IM. Front Psychiatry, 1544
Increased 2-arachidonoyl-sn-glycerol levels normalize cortical responses to sound and improve behaviors in Fmr1 KO mice. Pirbhoy PS, Jonak CR, Syed R, Argueta DA, Perez PA, Wiley MB, Hessamian K, Lovelace JW, Razak KA, DiPatrizio NV, Ethell IM, Binder DK. J Neurodev Disord 13 (1), 1-19
Urokinase plasminogen activator mediates changes in human astrocytes modeling fragile X syndrome. Peteri UK, Pitkonen K, de Toma I, Nieminen O, Utami KH, Strandin TM, Corcoran P, Roybon L, Vaheri A, Ethell IM, Casarotto P, Pouladi MA, Castrén ML. Glia 69 (12), 2947-2962
NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands. Baggio C, Kulinich AO, Dennys CN, Rodrigo R, Meyer K, Ethell IM, Pellecchia M. J med chem 64 (15), 11229-11246
Overactive Reproductive Axis Due to Fragile X Gene Mutation. Villa P, Lainez N, Ethell IM, Coss D. JES 5 (Suppl 1), A547
2020
Astrocytic ephrin-B1 controls excitatory-inhibitory balance in developing hippocampus. Nguyen AQ, Sutley S, Koeppen J, Mina K, Woodruff S, Hanna S, Vengala A, Hickmott PW, Obenaus A, Ethell IM. J Neurosci 40 (36), 6854-6871
Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome. Nguyen AQ, Binder DK, Ethell IM, Razak KA. J Neurophysiol. 2020 Jun 1;123(6):2101-2121. doi: 10.1152/jn.00706.2019.
Multielectrode array analysis of EEG biomarkers in a mouse model of Fragile X Syndrome. Jonak CR, Lovelace JW, Ethell IM, Razak KA, Binder DK. Neurobiol Dis. 2020 May;13(8):104794. doi: 10.1016/j.nbd.2020.104794.
Acute pharmacological inhibition of matrix metalloproteinase-9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice. Pirbhoy PS, Rais M, Lovelace JW, Woodard W, Razak KA, Binder DK, Ethell IM. J Neurochem. 2020 May 6. doi: 10.1111/jnc.15037.
Astrocytic Ephrin-B1 Controls Synapse Formation in the Hippocampus During Learning and Memory. Nguyen AQ, Koeppen J, Woodruff S, Mina K, Figueroa Z, Ethell IM. Front Synaptic Neurosci. 2020 Mar 17;12:10. doi: 10.3389/fnsyn.2020.00010.
Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome. Lovelace JW, Rais M, Palacios AR, Shuai XS, Bishay S, Popa O, Pirbhoy PS, Binder DK, Nelson DL, Ethell IM, Razak KA. Cereb Cortex. 2020 Mar 14;30(3):969-988. doi: 10.1093/cercor/bhz141.
Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome. Kulinich AO, Reinhard SM, Rais M, Lovelace JW, Scott V, Binder DK, Razak KA, Ethell IM. Neurobiol Dis. 2020 Feb;134:104622. doi: 10.1016/j.nbd.2019.104622.
2019
Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory. Reinhard SM, Rais M, Afroz S, Hanania Y, Pendi K, Espinoza K, Rosenthal R, Binder DK, Ethell IM, Razak KA. Neurobiol Learn Mem. 2019 Oct;164:107042. doi: 10.1016/j.nlm.2019.107042.
Reversal of ultrasonic vocalization deficits in a mouse model of Fragile X Syndrome with minocycline treatment or genetic reduction of MMP-9. Toledo MA, Wen TH, Binder DK, Ethell IM, Razak KA. Behav Brain Res. 2019 Oct 17;372:112068. doi: 10.1016/j.bbr.2019.112068.
Genetic reduction of MMP-9 in the Fmr1 KO mouse partially rescues prepulse inhibition of acoustic startle response. Kokash J, Alderson EM, Reinhard SM, Crawford CA, Binder DK, Ethell IM, Razak KA. Brain Res. 2019 Sep 15;1719:24-29. doi: 10.1016/j.brainres.2019.05.029.
Developmental Changes in EEG Phenotypes in a Mouse Model of Fragile X Syndrome. Wen TH, Lovelace JW, Ethell IM, Binder DK, Razak KA. Neurosci J. 2019 Feb 1;398:126-143. doi: 10.1016/j.neuroscience.2018.11.047.
2018
Reusable Multielectrode Array Technique for Electroencephalography in Awake Freely Moving Mice. Jonak CR, Lovelace JW, Ethell IM, Razak KA, Binder DK. Front Integr Neurosci. 2018 Oct 26;12:53. doi: 10.3389/fnint.2018.00053.
Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice. Lainez NM, Jonak CR, Nair MG, Ethell IM, Wilson EH, Carson MJ, Djurdjica Coss D. Frontiers immunol. 2018 Aug; 9:1-12. doi: 10.3389/fimmu.2018.01992
Functional Consequences of Synapse Remodeling Following Astrocyte-Specific Regulation of Ephrin-B1 in the Adult Hippocampus. Koeppen J, Nguyen AQ, Nikolakopoulou AM, Garcia M, Hanna S, Woodruff S, Figueroa Z, Obenaus A, Ethell IM. J Neurosci. 2018 Jun 20; 38(25):5710-5726.
Translation-relevant EEG phenotypes in a mouse model of Fragile X Syndrome. Lovelace JW, Ethell IM, Binder DK, Razak KA. Neurobiol Dis. 2018 Jul;115:39-48. doi: 10.1016/j.nbd.2018.03.012.
The Perineuronal 'Safety' Net? Perineuronal Net Abnormalities in Neurological Disorders. Wen TH, Binder DK, Ethell IM, Razak KA. Front Mol Neurosci, 11:270.
Sensory Processing Phenotypes in Fragile X Syndrome. Rais M, Binder DK, Razak KA, Ethell IM. ASN Neuro, 10, p.1759091418801092.
Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice. Wen TH, Afroz S, Reinhard S, Palacios A, Tapia K, Razak K, Ethell IM. Cereb Cortex. 2018 Nov 1;28(11):3951-3964. doi: 10.1093/cercor/bhx258.
2017
Automated spatio-temporal analysis of dendritic spines and related protein dynamics. On V, Zahedi A, Ethell IM, Bhanu B. PLoS One. 2017 Aug 21;12(8):e0182958.
Potent and Selective EphA4 Agonists for the Treatment of ALS. Wu B, De SK, Kulinich AO, Salem AF, Koeppen J, Wang R, Barile E, Wang S, Zhang D, Ethell IM and Pellecchia M. Cell Chem Biol, 24:1-13.
2016
GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii. David C, Frias E, Szu J, Vieira PA, Hubbard JA, Lovelace JW, Michael M, Worth D, McGovern KE, Ethell IM, Stanley GB, Fiacco TA, Binder DK, Wilson E. PLOS Pathogen. 2016 Jun 9;12(6):e1005643. doi: 10.1371/journal.ppat.1005643.
Astrocytic Ephrin-B1 Regulates Synapse Remodeling Following Traumatic Brain Injury. Nikolakopoulou AM, Koeppen J, Garcia M, Leish J, Obenaus A and Ethell IM. ASN Neuro, 2016 Feb 29;8(1):1-18. doi: 10.1177/1759091416630220.
Matrix metalloproteinase-9 deletion rescues auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome. Lovelace JW, Wen TH, Reinhard S, Hsu MS, Sidhu H, Ethell IM, Binder DK, Razak KA. Neurobiol dis. 2016 May;89:126-35. doi: 10.1016/j.nbd.2016.02.002.
2015
A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders. Reinhard S, Razak K, Ethell IM. Front cellular neurosci. 2015 Jul 29;9:280. doi: 10.3389/fncel.2015.00280.
2014
Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model. Sidhu H, Dansie LE, Hickmott PW, Ethell DW, Ethell IM. J Neuroscience. 2014 Jul 23;34(30):9867-79. doi: 10.1523/JNEUROSCI.1162-14.2014.
2013
Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice. Dansie LE, Phommahaxay K, Okusanya AG, Uwadia J, Huang M, Rotschafer SE, Razak KA, Ethell DW, Ethell IM. Neurosci j. 2013 246:186-198.
Optogenetics to target actin-mediated synaptic loss in Alzheimer’s. Zahedi A, Defea K, Ethell IM. SPIE: Optogenetics: Optical Methods for Cellular Control. V 8586:1-6.
2012
Cofilin under control of β-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning. Pontrello CG, Sun M-Y, Lin A, Fiacco TA, DeFea KA, Ethell IM. PNAS, 2012, 109(7):E442-51.
2011
Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome. Rotschafer SE, Trujillo MS, Dansie LE, Ethell IM, Razak KA. Brain Res., 2011, 1439:7-14.
Looking forward to EphB signaling in synapses. Sloniowski S, Ethell IM. Seminars in Cell and Dev Biol. Oct 21. 2011.
Casting a net on dendritic spines: the extracellular matrix and its receptors. Dansie LE, Ethell IM. Dev Neurobiol. 2011, 71(11): 956-981.
Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex. Cesa R, Premoselli F, Renna A, Ethell IM, Pasquale EB, Strata P. PLoS One. 2011, 6(4):e19160.
2010
Open-label add-on treatment trial of minocycline in fragile X syndrome. Paribello C, Tao L, Folino A, Berry-Kravis E, Tranfaglia M, Ethell IM, Ethell DW. BMC Neurol. 2010: p10:91.
Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures. Utari A, Chonchaiya W, Rivera SM, Schneider A, Hagerman RJ, Faradz SM, Ethell IM, Nguyen DV. Am J Intellect Dev Disabil. 2010 Vol. 115(5): p433-443.
The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand. Yang NY, Lopez-Bergami P, Goydos JS, Yip D, Walker AM, Pasquale EB, Ethell IM. Pigment Cell Melanoma Res. 2010. 23(5):684-687.
2009
Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines. Pontrello C, Ethell IM. TONJ, 2009, 3: 67-86.
Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity. Shi Y, Pontrello C, Defea K, Reichardt LF, Ethell IM. J. Neurosci., 2009, 29(25): 8075-8086.
Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. Bilousova T, Dansie LE, Ngo M, Aye J, Charles JR, Ethell DW, Ethell IM. J Med Gen., 2009, 46(2):94-102. Epub 2008 Oct 3.
2008
Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion. Lin KT, Ethell DW, Ethell IM. J Biol Chem, 2008, 283(43):28969-28979.
2007
Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets. Ethell IM, Ethell DW. J. Neurosci. Res. 2007. 85(13):2813-2823.
2006
Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation. Bilousova T, Rusakov D, Ethell DW, Ethell IM. J neurochem. 2006. 97(1):44-56.
Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+/calmodulin-dependent protein kinase II-mediated actin reorganization. Shi Y, Ethell IM. J. Neurosci. 2006. 26(6):1813-1822.
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation. Moeller ML, Shi Y, Reichardt LF, Ethell IM. J Biol Chem. 2006. 281(3):1587-98.
2005
GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, Sheng M. Nat Neurosci. 2005. 8(7):906-915.
2003
Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. Henkemeyer M, Itkis OS, Ngo M, Hickmott PW, Ethell IM. J Cell Biol., 2003, 163(6):1313-1326.